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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1566064
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prrc2c
Name: proline-rich coiled-coil 2C
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prrc2cdecreases expressionISOPRRC2C (Homo sapiens)6480464CTDCisplatin results in decreased expression of PRRC2C mRNAPMID:27594783
Prrc2cdecreases phosphorylationISOPrrc2c (Mus musculus)6480464CTDCisplatin results in decreased phosphorylation of PRRC2C proteinPMID:22006019
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