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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1565835
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Wfikkn1
Name: WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Wfikkn1affects methylationISOWFIKKN1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of WFIKKN1 5' UTR; Benzo(a)pyrene affects the methylation of WFIKKN1 promoterPMID:27901495
Wfikkn1decreases expressionISOWFIKKN1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of WFIKKN1 mRNAPMID:26238291
Wfikkn1increases methylationISOWfikkn1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased methylation of WFIKKN1 promoterPMID:27901495
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