Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1561797
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cks1b
Name: CDC28 protein kinase regulatory subunit 1B
Acc ID: CHEBI:5118
Term: fluoxetine
Definition: A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
Chemical ID: MESH:D005473
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cks1bdecreases expressionISOCKS1B (Homo sapiens)6480464CTDFluoxetine results in decreased expression of CKS1B mRNAPMID:18371935
Cks1bmultiple interactionsISOCKS1B (Homo sapiens)6480464CTD[Fluoxetine results in decreased activity of CKS1B protein] which results in decreased degradation of CCNE1 protein; [Fluoxetine results in decreased activity of CKS1B protein] which results in decreased degradation of CDKN1A protein; [Fluoxetine results in decreased activity of CKS1B protein] which results in decreased degradation of CDKN1B protein; Fluoxetine binds to and results in decreased activity of CKS1B proteinPMID:18371935
Go Back to source page   Continue to Ontology report