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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1559609
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Wwtr1
Name: WW domain containing transcription regulator 1
Acc ID: CHEBI:75142
Term: N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal
Definition: A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.
Chemical ID: MESH:C072553
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Wwtr1multiple interactionsISOWWTR1 (Homo sapiens)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of WWTR1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [tcdA protein, Clostridium difficile results in decreased expression of WWTR1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [toxB protein, Clostridium difficile results in decreased expression of WWTR1 protein]PMID:33251692 PMID:33539684
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