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GENE - TERM ANNOTATION REPORT

RGD ID: 1551835
Species: Mus musculus
RGD Object: Gene
Symbol: Smn1
Name: survival motor neuron 1
Acc ID: GO:0015030
Term: Cajal body
Definition: A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA.
Definition Source(s): NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smn1is_active_inIBAPANTHER:PTN002299200 or MGI:109257 or UniProtKB:Q166372290270GO_Central GO_REF:0000033
Smn1located_inISOUniProtKB:Q166372290270GO_Central GO_REF:0000119
Smn1located_inIDA 2290270MGI PMID:24067532

PMID:24067532
Smn1located_inISSUniProtKB:Q166372290270UniProt GO_REF:0000024
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