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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 14170248
Species: Sus scrofa
RGD Object: Gene
Symbol: NFE2L2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:27744
Term: glyphosate
Definition: A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS).
Chemical ID: MESH:C010974
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NFE2L2increases expressionEXP 6480464CTDGlyphosate results in increased expression of NFE2L2 mRNA; Glyphosate results in increased expression of NFE2L2 proteinPMID:31677563 PMID:35388968 PMID:36584959
NFE2L2multiple interactionsEXP 6480464CTDBetaine inhibits the reaction [Glyphosate results in increased expression of NFE2L2 mRNA]; Glyphosate results in increased expression of and affects the localization of NFE2L2 proteinPMID:35388968 PMID:36584959
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