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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 14051082
Species: Sus scrofa
RGD Object: Gene
Symbol: PTGS2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PTGS2increases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of PTGS2 mRNAPMID:26180592 PMID:27861533
PTGS2multiple interactionsEXP 6480464CTD3',4',5'-trimethoxyflavone analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]PMID:26180592 PMID:27861533
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