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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359338
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nhej1
Name: nonhomologous end-joining factor 1
Acc ID: CHEBI:40036
Term: amitrole
Definition: A member of the class of triazoles that is 1H-1,2,4-triazole substituted by an amino group at position 3. Used to control annual grasses and aquatic weeds (but not on food crops because it causes cancer in laboratory animals). Its use within the EU was banned from September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties.
Chemical ID: MESH:D000640
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nhej1decreases expressionEXP 6480464CTDAmitrole results in decreased expression of NHEJ1 mRNAPMID:30047161
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