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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1353500
Species: Homo sapiens
RGD Object: Gene
Symbol: EIF4EBP1
Name: eukaryotic translation initiation factor 4E binding protein 1
Acc ID: CHEBI:72690
Term: pomalidomide
Definition: An aromatic amine that is thalidomide substituted at position 4 on the isoindole ring system by an amino group. Used for the treatment of multiple myeloma in patients who failed to respond to previous therapies.
Chemical ID: MESH:C467566
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EIF4EBP1multiple interactionsEXP 6480464CTD[pomalidomide co-treated with Dexamethasone] results in decreased phosphorylation of EIF4EBP1 protein; afuresertib promotes the reaction [[pomalidomide co-treated with Dexamethasone] results in decreased phosphorylation of EIF4EBP1 protein]PMID:29928335
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