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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1351569
Species: Homo sapiens
RGD Object: Gene
Symbol: ORM1
Name: orosomucoid 1
Acc ID: CHEBI:10033
Term: warfarin
Definition: A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.
Chemical ID: MESH:D014859
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ORM1affects bindingEXP 6480464CTDWarfarin binds to ORM1 protein alternative formPMID:8946472
ORM1affects response to substanceEXP 6480464CTDORM1 gene polymorphism affects the susceptibility to Warfarin; ORM1 polymorphism affects the susceptibility to WarfarinPMID:17496169 PMID:23208322 PMID:26644206
ORM1increases response to substanceEXP 6480464CTDORM1 protein results in increased susceptibility to WarfarinPMID:17496169
ORM1multiple interactionsEXP 6480464CTDChlorpromazine inhibits the reaction [Warfarin binds to ORM1 protein alternative form]; Dipyridamole inhibits the reaction [Warfarin binds to ORM1 protein alternative form]; Lidocaine inhibits the reaction [Warfarin binds to ORM1 protein alternative form]; Progesterone inhibits the reaction [Warfarin binds to ORM1 protein alternative form]PMID:8946472
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