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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347299
Species: Homo sapiens
RGD Object: Gene
Symbol: SMAD2
Name: SMAD family member 2
Acc ID: CHEBI:70436
Term: platycodin D
Definition: A triterpenoid saponin that has formula C57H92O28.
Chemical ID: MESH:C108953
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SMAD2multiple interactionsEXP 6480464CTD[platycodin D co-treated with osthol] inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; [platycodin D co-treated with osthol] results in decreased expression of SMAD2 mRNA; [platycodin D co-treated with osthol] results in decreased expression of SMAD2 proteinPMID:23603464
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