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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347299
Species: Homo sapiens
RGD Object: Gene
Symbol: SMAD2
Name: SMAD family member 2
Acc ID: CHEBI:52646
Term: leptomycin B
Definition: A leptomycin having a (2E,10E,12E,16Z,18E)-double bond configuration as well as an ethyl substituent at position 17.
Chemical ID: MESH:C038753
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SMAD2multiple interactionsISOSmad2 (Mus musculus)6480464CTDleptomycin B inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]; leptomycin B inhibits the reaction [arsenite inhibits the reaction [XPO4 protein results in increased export of SMAD2 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [XPO4 protein results in increased export of SMAD2 protein]]PMID:26354774
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