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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347299
Species: Homo sapiens
RGD Object: Gene
Symbol: SMAD2
Name: SMAD family member 2
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SMAD2decreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of SMAD2 mRNAPMID:25258189
SMAD2increases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of SMAD2 mRNAPMID:32240679
SMAD2multiple interactionsEXP 6480464CTDArsenic Trioxide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; RNF4 protein affects the reaction [Arsenic Trioxide results in increased expression of SMAD2 mRNA]; UBE2I protein affects the reaction [Arsenic Trioxide results in increased expression of SMAD2 mRNA]PMID:24762191 PMID:30317545 PMID:32240679
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