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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345686
Species: Homo sapiens
RGD Object: Gene
Symbol: CXCL8
Name: C-X-C motif chemokine ligand 8
Acc ID: CHEBI:529996
Term: cytochalasin D
Definition: An organic heterotricyclic compound that is a mycotoxin produced by Helminthosporium and other moulds which is cell permeable and a potent inhibitor of actin polymerisation and DNA synthesis.
Chemical ID: MESH:D015638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CXCL8increases stabilityEXP 6480464CTDCytochalasin D results in increased stability of CXCL8 mRNAPMID:16499908
CXCL8multiple interactionsEXP 6480464CTDCytochalasin D inhibits the reaction [Asbestos, Serpentine results in increased secretion of CXCL8 protein]; Cytochalasin D inhibits the reaction [Particulate Matter results in increased expression of CXCL8 protein]; Cytochalasin D inhibits the reaction [Smoke results in increased expression of CXCL8 mRNA]; Cytochalasin D inhibits the reaction [Smoke results in increased secretion of CXCL8 protein]; Cytochalasin D inhibits the reaction [Titanium results in increased secretion of CXCL8 protein]; Cytochalasin D inhibits the reaction [Vehicle Emissions results in increased expression of CXCL8 mRNA]; Cytochalasin D promotes the reaction [CXCL8 protein results in decreased expression of CXCR1 protein]; Cytochalasin D promotes the reaction [CXCL8 protein results in decreased expression of CXCR2 protein]PMID:11145710 PMID:16392133 PMID:23670201 PMID:26303504 PMID:8089496
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