GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CXCL8 | decreases expression | EXP | | 6480464 | CTD | Atorvastatin results in decreased expression of CXCL8 mRNA; Atorvastatin results in decreased expression of CXCL8 protein | PMID:12117737 PMID:16410222 | CXCL8 | decreases secretion | EXP | | 6480464 | CTD | Atorvastatin results in decreased secretion of CXCL8 protein | PMID:16387846 | CXCL8 | increases expression | EXP | | 6480464 | CTD | Atorvastatin results in increased expression of CXCL8 protein | PMID:19171469 | CXCL8 | multiple interactions | EXP | | 6480464 | CTD | Atorvastatin inhibits the reaction [Air Pollutants results in increased expression of CXCL8 mRNA]; Atorvastatin inhibits the reaction [Air Pollutants results in increased expression of CXCL8 protein]; Atorvastatin inhibits the reaction [Particulate Matter results in increased expression of CXCL8 mRNA]; Atorvastatin inhibits the reaction [Particulate Matter results in increased expression of CXCL8 protein]; Atorvastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]; Atorvastatin promotes the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein]; Atorvastatin results in decreased expression of and results in decreased secretion of CXCL8 protein; Mevalonic Acid inhibits the reaction [Atorvastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]]; Mevalonic Acid inhibits the reaction [Atorvastatin results in decreased expression of CXCL8 mRNA] | PMID:12117737 PMID:16387846 PMID:19482827 | | ||||||||||||||||||||||
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