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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344181
Species: Homo sapiens
RGD Object: Gene
Symbol: NCOA3
Name: nuclear receptor coactivator 3
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NCOA3affects localizationEXP 6480464CTDEstradiol affects the localization of NCOA3 proteinPMID:20079471
NCOA3decreases expressionEXP 6480464CTDEstradiol results in decreased expression of NCOA3 mRNA; Estradiol results in decreased expression of NCOA3 proteinPMID:16474171 PMID:16739346
NCOA3increases activityEXP 6480464CTDEstradiol results in increased activity of NCOA3 proteinPMID:28704378
NCOA3increases expressionEXP 6480464CTDEstradiol results in increased expression of NCOA3 mRNAPMID:31646340
NCOA3increases phosphorylationEXP 6480464CTDEstradiol results in increased phosphorylation of NCOA3 proteinPMID:17157789
NCOA3multiple interactionsEXP 6480464CTD(+)-JQ1 compound affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to GREB1 promoter]]; (+)-JQ1 compound inhibits the reaction [Estradiol promotes the reaction [NCOA3 protein binds to XBP1 promoter]]; afimoxifene inhibits the reaction [Estradiol results in increased activity of NCOA3 protein]; bazedoxifene inhibits the reaction [Estradiol results in increased activity of NCOA3 protein]; benzamide analog inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA3 protein]]; BRCA1 protein affects the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA3 protein]]; ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to H19 gene]]; ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to KLRC1 gene]]; ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to NKD1 gene]]; ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to SPATA13 gene]]; ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to TMEM121B gene]]; Estradiol inhibits the reaction [NCOA3 protein binds to CCNG2 promoter]; Estradiol inhibits the reaction [TNF protein inhibits the reaction [NCOA3 protein binds to IL6 promoter]]; Estradiol promotes the reaction [[ESR1 protein binds to NCOA3 protein] which binds to TFF1 promoter]; Estradiol promotes the reaction [[NCOA3 protein binds to CYP2B6 promoter] which results in increased expression of CYP2B6 mRNA]; Estradiol promotes the reaction [ESR1 protein binds to NCOA3 protein]; Estradiol promotes the reaction [NCOA3 protein binds to ESR1 promoter]; Estradiol promotes the reaction [NCOA3 protein binds to ESR1 protein]; Estradiol promotes the reaction [NCOA3 protein binds to GREB1 enhancer]; Estradiol promotes the reaction [NCOA3 protein binds to GREB1 promoter]; Estradiol promotes the reaction [NCOA3 protein binds to IGF1 promoter]; Estradiol promotes the reaction [NCOA3 protein binds to KLRC3 gene]; Estradiol promotes the reaction [NCOA3 protein binds to PTGS2 promoter]; Estradiol promotes the reaction [NCOA3 protein binds to TFF1 promoter]; Estradiol promotes the reaction [NCOA3 protein binds to XBP1 promoter]; Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [NCOA3 protein binds to CYP1B1 promoter]]; NCOA3 mutant form inhibits the reaction [Estradiol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; Tetrachlorodibenzodioxin inhibits the reaction [Estradiol inhibits the reaction [NCOA3 protein binds to CCNG2 promoter]]PMID:17157789 PMID:17395694 PMID:17872375 PMID:17962382 PMID:18997820 PMID:19620290 PMID:20079471 PMID:20846786 PMID:22596188 PMID:23665804 PMID:24299737 PMID:24771768 PMID:25721606 PMID:27156127 PMID:28704378 PMID:29389661 PMID:32088792
NCOA3increases expressionISONcoa3 (Rattus norvegicus)6480464CTDEstradiol results in increased expression of NCOA3 mRNAPMID:20068009
NCOA3multiple interactionsISONcoa3 (Mus musculus)6480464CTDNCOA3 protein promotes the reaction [Estradiol results in increased expression of ESR2 protein alternative form]PMID:27634370
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