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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1322217
Species: Mus musculus
RGD Object: Gene
Symbol: Mecom
Name: MDS1 and EVI1 complex locus
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mecomdecreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of MECOM mRNAPMID:22228805
Mecomincreases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of MECOM mRNAPMID:32417428
Mecomaffects expressionISOMECOM (Homo sapiens)6480464CTDBenzo(a)pyrene affects the expression of MECOM mRNAPMID:21714911
Mecomaffects methylationISOMECOM (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of MECOM intron; Benzo(a)pyrene affects the methylation of MECOM promoterPMID:27901495 PMID:30157460
Mecomdecreases methylationISOMECOM (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of MECOM 5' UTRPMID:27901495
Mecomincreases methylationISOMECOM (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of MECOM 3' UTRPMID:27901495
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