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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1321067
Species: Homo sapiens
RGD Object: Gene
Symbol: TFAP2A
Name: transcription factor AP-2 alpha
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TFAP2Aincreases expressionEXP 6480464CTDDoxorubicin results in increased expression of TFAP2A proteinPMID:16204029
TFAP2Aincreases response to substanceEXP 6480464CTDTFAP2A protein results in increased susceptibility to DoxorubicinPMID:16204029
TFAP2Amultiple interactionsEXP 6480464CTD[decitabine results in increased expression of TFAP2A protein] which results in increased susceptibility to DoxorubicinPMID:16204029
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