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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1320482
Species: Homo sapiens
RGD Object: Gene
Symbol: POLH
Name: DNA polymerase eta
Acc ID: CHEBI:30614
Term: benzo[a]pyrene diol epoxide I
Definition: An epoxide that has formula C20H14O3.
Chemical ID: MESH:D015123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
POLHincreases response to substanceEXP 6480464CTDPOLH results in increased susceptibility to 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxidePMID:22745795
POLHmultiple interactionsEXP 6480464CTDPOLH mutant form inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased mutagenesis of HPRT1 gene]PMID:22745795
POLHaffects response to substanceISOPolh (Mus musculus)6480464CTDPOLH protein affects the susceptibility to 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxidePMID:22331492
POLHincreases response to substanceISOPolh (Mus musculus)6480464CTDPOLH results in increased susceptibility to 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxidePMID:22745795
POLHmultiple interactionsISOPolh (Mus musculus)6480464CTDPOLH mutant form inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased mutagenesis of HPRT1 gene]; POLH protein affects the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased phosphorylation of CHEK1 protein]; POLH protein affects the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased phosphorylation of H2AX protein]PMID:22331492 PMID:22745795
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