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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1320482
Species: Homo sapiens
RGD Object: Gene
Symbol: POLH
Name: DNA polymerase eta
Acc ID: CHEBI:131848
Term: fotemustine
Definition: A racemate comprising equimolar amounts of (R)- and (S)-fotemustine. It is an alkylating agent used in the treatment of malignant melanoma.
Chemical ID: MESH:C054368
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
POLHdecreases response to substanceEXP 6480464CTDPOLH protein results in decreased susceptibility to fotemustinePMID:25125662
POLHincreases expressionEXP 6480464CTDfotemustine results in increased expression of POLH mRNA; fotemustine results in increased expression of POLH proteinPMID:25125662
POLHmultiple interactionsEXP 6480464CTDDactinomycin inhibits the reaction [fotemustine results in increased expression of POLH mRNA]; fotemustine promotes the reaction [TP53 protein binds to POLH promoter]; pifithrin inhibits the reaction [fotemustine results in increased expression of POLH mRNA]; pifithrin inhibits the reaction [fotemustine results in increased expression of POLH protein]PMID:25125662
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