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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1319590
Species: Mus musculus
RGD Object: Gene
Symbol: Irx4
Name: Iroquois homeobox 4
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Irx4affects methylationEXP 6480464CTDbisphenol A affects the methylation of IRX4 promoterPMID:27334623
Irx4decreases expressionISOIrx4 (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of IRX4 mRNAPMID:25181051
Irx4decreases methylationISOIRX4 (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of IRX4 genePMID:31601247
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