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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1317785
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp2c65
Name: cytochrome P450, family 2, subfamily c, polypeptide 65
Acc ID: CHEBI:15843
Term: arachidonic acid
Definition: A long-chain fatty acid that is a C20, polyunsaturated fatty acid having four (Z)-double bonds at positions 5, 8, 11 and 14.
Chemical ID: MESH:D016718
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2c65decreases activityISOCYP2C9 (Homo sapiens)6480464CTDArachidonic Acid results in decreased activity of CYP2C9 proteinPMID:16978661
Cyp2c65increases metabolic processingISOCYP2C9 (Homo sapiens)6480464CTDCYP2C9 protein results in increased metabolism of Arachidonic AcidPMID:12675279
Cyp2c65multiple interactionsISOCYP2C9 (Homo sapiens)6480464CTDCYP2C9 protein results in increased metabolism of [Arachidonic Acid co-treated with NADP]; Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased metabolism of Arachidonic Acid]PMID:12675279 PMID:16978661
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