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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1317502
Species: Homo sapiens
RGD Object: Gene
Symbol: SH2D4A
Name: SH2 domain containing 4A
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SH2D4Aincreases expressionEXP 6480464CTDCalcitriol results in increased expression of SH2D4A mRNAPMID:21592394
SH2D4Amultiple interactionsEXP 6480464CTD[Testosterone co-treated with Calcitriol] results in increased expression of SH2D4A mRNAPMID:21592394
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