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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1314216
Species: Homo sapiens
RGD Object: Gene
Symbol: LATS2
Name: large tumor suppressor kinase 2
Acc ID: CHEBI:88217
Term: N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine
Definition: An N-substituted diamine that is ethylenediamine in which the four amino hydrogens are replaced by 2-pyridylmethyl groups.
Chemical ID: MESH:C044387
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
LATS2decreases expressionEXP 6480464CTDN,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of LATS2 mRNAPMID:18778698
LATS2multiple interactionsEXP 6480464CTDN,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc binds to LATS2 protein]; TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of LATS2 mRNA]PMID:18778698 PMID:35027733
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