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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1312683
Species: Homo sapiens
RGD Object: Gene
Symbol: EZH2
Name: enhancer of zeste 2 polycomb repressive complex 2 subunit
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EZH2decreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of EZH2 mRNA; Arsenic Trioxide results in decreased expression of EZH2 proteinPMID:30612216 PMID:35467087
EZH2decreases response to substanceEXP 6480464CTDEZH2 protein results in decreased susceptibility to Arsenic TrioxidePMID:26592252
EZH2increases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of EZH2 proteinPMID:26592252
EZH2multiple interactionsEXP 6480464CTDArsenic Trioxide inhibits the reaction [EZH2 protein binds to RELA protein]PMID:30612216
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