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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311376
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp19
Name: matrix metallopeptidase 19
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp19decreases methylationISOMMP19 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of MMP19 promoterPMID:27901495
Mmp19increases expressionISOMMP19 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of MMP19 mRNAPMID:22316170 PMID:32234424
Mmp19increases mutagenesisISOMMP19 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased mutagenesis of MMP19 genePMID:25435355
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