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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309908
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rap1gap
Name: Rap1 GTPase-activating protein
Acc ID: CHEBI:50131
Term: 5-aza-2'-deoxycytidine
Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4.
Chemical ID: MESH:C014347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rap1gapdecreases methylationISORAP1GAP (Homo sapiens)6480464CTDDecitabine results in decreased methylation of RAP1GAP promoterPMID:19147557
Rap1gapincreases expressionISORAP1GAP (Homo sapiens)6480464CTDDecitabine results in increased expression of RAP1GAP mRNA; Decitabine results in increased expression of RAP1GAP proteinPMID:19147557
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