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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309908
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rap1gap
Name: Rap1 GTPase-activating protein
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rap1gapincreases expressionEXP 6480464CTDAflatoxin B1 results in increased expression of RAP1GAP mRNAPMID:25378103 PMID:33354967
Rap1gapdecreases methylationISORAP1GAP (Homo sapiens)6480464CTDAflatoxin B1 results in decreased methylation of RAP1GAP exon; Aflatoxin B1 results in decreased methylation of RAP1GAP intronPMID:30157460
Rap1gapincreases expressionISORAP1GAP (Homo sapiens)6480464CTDAflatoxin B1 results in increased expression of RAP1GAP mRNAPMID:32234424
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