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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309725
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dvl2
Name: dishevelled segment polarity protein 2
Acc ID: CHEBI:7553
Term: niclosamide
Definition: A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.
Chemical ID: MESH:D009534
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dvl2multiple interactionsEXP 6480464CTDNiclosamide inhibits the reaction [Thioacetamide results in increased expression of DVL2 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of DVL2 mRNA]]PMID:32961231
Dvl2decreases expressionISODVL2 (Homo sapiens)6480464CTDNiclosamide results in decreased expression of DVL2 proteinPMID:19772353 PMID:21531761 PMID:30143678
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