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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309543
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppp1r18
Name: protein phosphatase 1, regulatory subunit 18
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppp1r18decreases methylationISOPpp1r18 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased methylation of PPP1R18 promoterPMID:27901495
Ppp1r18increases expressionISOPPP1R18 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of PPP1R18 mRNAPMID:26238291 PMID:32234424
Ppp1r18increases methylationISOPPP1R18 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of PPP1R18 3' UTR; Benzo(a)pyrene results in increased methylation of PPP1R18 promoterPMID:27901495
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