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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309415
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nlrp12
Name: NLR family, pyrin domain containing 12
Acc ID: CHEBI:52717
Term: bortezomib
Definition: L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.
Chemical ID: MESH:D000069286
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nlrp12increases expressionISONLRP12 (Homo sapiens)6480464CTDBortezomib results in increased expression of NLRP12 mRNAPMID:20471514
Nlrp12multiple interactionsISONLRP12 (Homo sapiens)6480464CTDBortezomib promotes the reaction [arsenic trioxide results in increased expression of NLRP12 mRNA]PMID:20471514
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