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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309329
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lrp5
Name: LDL receptor related protein 5
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lrp5increases expressionEXP 6480464CTDCurcumin results in increased expression of LRP5 mRNAPMID:25963729
Lrp5multiple interactionsEXP 6480464CTDCurcumin inhibits the reaction [bisphenol A results in decreased expression of LRP5 mRNA]PMID:25963729
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