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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309211
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdt1
Name: chromatin licensing and DNA replication factor 1
Acc ID: CHEBI:4393
Term: (-)-demecolcine
Definition: A secondary amino compound that is (S)-colchicine in which the N-acetyl group is replaced by an N-methyl group. Isolable from the autumn crocus, Colchicum autumnale, it is less toxic than colchicine and is used as an antineoplastic.
Chemical ID: MESH:D003703
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdt1decreases expressionISOCDT1 (Homo sapiens)6480464CTDDemecolcine results in decreased expression of CDT1 mRNAPMID:23649840
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