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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309129
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ndufb8
Name: NADH:ubiquinone oxidoreductase subunit B8
Acc ID: CHEBI:9747
Term: Triptolide
Definition: An oxacycle that has formula C20H24O6.
Chemical ID: MESH:C001899
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ndufb8decreases expressionEXP 6480464CTDtriptolide results in decreased expression of NDUFB8 mRNA; triptolide results in decreased expression of NDUFB8 proteinPMID:36436616
Ndufb8multiple interactionsEXP 6480464CTD7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 mRNA]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 protein]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 protein]]; SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 mRNA]]PMID:36436616
Ndufb8decreases expressionISONdufb8 (Mus musculus)6480464CTDtriptolide results in decreased expression of NDUFB8 proteinPMID:36436616
Ndufb8multiple interactionsISONdufb8 (Mus musculus)6480464CTD7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 protein]PMID:36436616
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