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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308582
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Shmt2
Name: serine hydroxymethyltransferase 2
Acc ID: CHEBI:379896
Term: 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one
Definition: A synthetic non-aromatisable androgen and anabolic steroid. It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors.
Chemical ID: MESH:D015741
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Shmt2multiple interactionsISOSHMT2 (Homo sapiens)6480464CTDMetribolone promotes the reaction [NDRG1 protein binds to SHMT2 protein]PMID:17220478
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