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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307814
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Zyg11b
Name: zyg-11 family member B, cell cycle regulator
Acc ID: CHEBI:64153
Term: tanespimycin
Definition: A 19-membered macrocyle that is geldanamycin in which the methoxy substituent attached to the benzoquinone moiety has been replaced by an allylamino group. It is a potent inhibitor of heat shock protein 90 (Hsp90). A less toxic analogue than geldanamycin, it induces apoptosis and displays antitumour effects.
Chemical ID: MESH:C112765
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Zyg11bincreases expressionISOZYG11B (Homo sapiens)6480464CTDtanespimycin analog results in increased expression of ZYG11B proteinPMID:31370342
Zyg11bmultiple interactionsISOZYG11B (Homo sapiens)6480464CTD[tanespimycin co-treated with VER 155008] results in increased expression of ZYG11B proteinPMID:31370342
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