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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306831
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stim1
Name: stromal interaction molecule 1
Acc ID: CHEBI:32234
Term: titanium dioxide
Definition: A titanium oxide with the formula TiO2. A naturally occurring oxide sourced from ilmenite, rutile and anatase, it has a wide range of applications.
Chemical ID: MESH:C009495
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stim1decreases methylationISOSTIM1 (Homo sapiens)6480464CTDtitanium dioxide results in decreased methylation of STIM1 gene; titanium dioxide results in decreased methylation of STIM1 promoterPMID:34973136
Stim1decreases methylationISOStim1 (Mus musculus)6480464CTDtitanium dioxide results in decreased methylation of STIM1 genePMID:35295148
Stim1increases methylationISOStim1 (Mus musculus)6480464CTDtitanium dioxide results in increased methylation of STIM1 promoterPMID:35295148
Stim1multiple interactionsISOStim1 (Mus musculus)6480464CTD[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of STIM1 mRNAPMID:29950665
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