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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306737
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aldh1b1
Name: aldehyde dehydrogenase 1 family, member B1
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aldh1b1decreases expressionISOALDH1B1 (Homo sapiens)6480464CTDPhenobarbital results in decreased expression of ALDH1B1 proteinPMID:35881160
Aldh1b1decreases expressionISOAldh1b1 (Mus musculus)6480464CTDPhenobarbital results in decreased expression of ALDH1B1 mRNA; Phenobarbital results in decreased expression of ALDH1B1 proteinPMID:19482888 PMID:35881160
Aldh1b1multiple interactionsISOAldh1b1 (Mus musculus)6480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of ALDH1B1 mRNA; NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of ALDH1B1 mRNA]PMID:19482888 PMID:24535843
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