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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305705
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Otx2
Name: orthodenticle homeobox 2
Acc ID: CHEBI:34608
Term: captan
Definition: A dicarboximide that is 3a,4,7,7a-tetrahydrophthalimide in which the hydrogen attached to the nitrogen is replaced by a trichloromethyl group. A non-systemic fungicide introduced in the 1950s, it is widely used for the control of fungal diseases in fruits, vegetables, and ornamental crops.
Chemical ID: MESH:D002215
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Otx2multiple interactionsISOOTX2 (Homo sapiens)6480464CTDCaptan promotes the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of OTX2 mRNA]PMID:32949729
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