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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305346
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Farp1
Name: FERM, ARH/RhoGEF and pleckstrin domain protein 1
Acc ID: CHEBI:44616
Term: afimoxifene
Definition: A tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen.
Chemical ID: MESH:C016601
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Farp1increases expressionISOFARP1 (Homo sapiens)6480464CTDafimoxifene results in increased expression of FARP1 mRNAPMID:16849584
Farp1multiple interactionsISOFARP1 (Homo sapiens)6480464CTDESR2 protein inhibits the reaction [afimoxifene results in increased expression of FARP1 mRNA]; Estradiol inhibits the reaction [afimoxifene results in increased expression of FARP1 mRNA]; Fulvestrant inhibits the reaction [afimoxifene results in increased expression of FARP1 mRNA]PMID:16849584
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