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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305346
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Farp1
Name: FERM, ARH/RhoGEF and pleckstrin domain protein 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Farp1affects methylationISOFARP1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of FARP1 3' UTR; Benzo(a)pyrene affects the methylation of FARP1 5' UTRPMID:27901495
Farp1decreases expressionISOFARP1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of FARP1 mRNAPMID:20106945 PMID:21632981 PMID:26238291
Farp1decreases expressionISOFarp1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of FARP1 mRNAPMID:19770486
Farp1increases methylationISOFARP1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of FARP1 promoterPMID:27901495
Farp1increases mutagenesisISOFARP1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased mutagenesis of FARP1 genePMID:25435355
Farp1multiple interactionsISOFarp1 (Mus musculus)6480464CTD[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of FARP1 mRNAPMID:27858113
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