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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1304918
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Asf1b
Name: anti-silencing function 1B histone chaperone
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Asf1bdecreases expressionISOAsf1b (Mus musculus)6480464CTDFolic Acid results in decreased expression of ASF1B mRNAPMID:25629700
Asf1bmultiple interactionsISOASF1B (Homo sapiens)6480464CTD[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of ASF1B mRNAPMID:24657277
Asf1bmultiple interactionsISOAsf1b (Mus musculus)6480464CTD[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of ASF1B; [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ASF1B gene; [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ASF1B mRNAPMID:20938992
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