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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303284
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Trpa1
Name: transient receptor potential cation channel, subfamily A, member 1
Acc ID: CHEBI:15368
Term: acrolein
Definition: An enal that is prop-2-ene with an oxo group at position 1.
Chemical ID: MESH:D000171
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Trpa1increases activityEXP 6480464CTDAcrolein results in increased activity of TRPA1 proteinPMID:18568077
Trpa1affects response to substanceISOTRPA1 (Homo sapiens)6480464CTDTRPA1 mRNA affects the susceptibility to AcroleinPMID:19507004
Trpa1affects response to substanceISOTrpa1 (Mus musculus)6480464CTDTRPA1 gene mutant form affects the susceptibility to Acrolein; TRPA1 protein affects the susceptibility to AcroleinPMID:27746315 PMID:30351402
Trpa1decreases response to substanceISOTrpa1 (Mus musculus)6480464CTDTRPA1 gene mutant form results in decreased susceptibility to AcroleinPMID:29627347
Trpa1increases activityISOTRPA1 (Homo sapiens)6480464CTDAcrolein results in increased activity of TRPA1 proteinPMID:21591660
Trpa1increases activityISOTrpa1 (Mus musculus)6480464CTDAcrolein results in increased activity of TRPA1 proteinPMID:18568077 PMID:34271065
Trpa1increases response to substanceISOTrpa1 (Mus musculus)6480464CTDTRPA1 gene mutant form results in increased susceptibility to AcroleinPMID:27592100
Trpa1multiple interactionsISOTRPA1 (Homo sapiens)6480464CTDTRPA1 mRNA affects the reaction [Acrolein results in increased secretion of Serotonin]; TRPA1 mRNA affects the reaction [Acrolein results in increased uptake of Calcium]PMID:19507004
Trpa1multiple interactionsISOTrpa1 (Mus musculus)6480464CTDTRPA1 gene mutant form affects the susceptibility to [Particulate Matter co-treated with Acrolein]PMID:30351402
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