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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1302952
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cops4
Name: COP9 signalosome subunit 4
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cops4increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of COPS4 mRNAPMID:33387578
Cops4affects expressionISOCops4 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of COPS4 mRNAPMID:21570461
Cops4multiple interactionsISOCops4 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COPS4 mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to COPS4 promoter]PMID:17942748 PMID:19654925
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