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GENE - TERM ANNOTATION REPORT

RGD ID: 11842193
Species: Pan paniscus
RGD Object: Gene
Symbol: ANK2
Name: ankyrin 2
Acc ID: DOID:9005444
Term: Torsades de Pointes
Definition: A malignant form of polymorphic ventricular tachycardia that is characterized by HEART RATE between 200 and 250 beats per minute, and QRS complexes with changing amplitude and twisting of the points. The term also describes the syndrome of tachycardia with prolonged ventricular repolarization, long QT intervals exceeding 500 milliseconds or BRADYCARDIA. Torsades de pointes may be self-limited or may progress to VENTRICULAR FIBRILLATION.
Definition Source(s): MESH:D016171
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ANK2 ISOANK2 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Torsades de pointesPMID:17161064 PMID:22581653 PMID:28492532
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