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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11160
Species: Mus musculus
RGD Object: Gene
Symbol: Prnp
Name: prion protein
Acc ID: CHEBI:63041
Term: manganese(II) chloride
Definition: An inorganic chloride in which manganese(II) is coordinated to two chloride ions. In its anhydrous state manganese(II) chloride is a polymeric solid, which adopts a layered cadmium chloride-like structure.
Chemical ID: MESH:C025340
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prnpdecreases response to substanceEXP 6480464CTDPRNP protein results in decreased susceptibility to manganese chloridePMID:17483122
Prnpmultiple interactionsEXP 6480464CTDPRNP protein inhibits the reaction [manganese chloride results in decreased abundance of Glutathione]; PRNP protein inhibits the reaction [manganese chloride results in increased activity of CASP3 protein]; PRNP protein inhibits the reaction [manganese chloride results in increased activity of CASP9 protein]; PRNP protein inhibits the reaction [manganese chloride results in increased chemical synthesis of Reactive Oxygen Species]PMID:17483122
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