| F344 |
number of abdominal retractions |
4-methyl-2-(piperidin-1-yl)-quinoline (1 mg/kg) (for 0.5 hours) then Allyl isothiocyanate (0.5 %) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
chemical nociception trait |
male |
days
| 4 |
10.66 |
null |
5.4 |
10.8 |
visual assessment of in vivo video recording |
1500.0 |
|
|
stretch/retract abdomon |
105559 |
3018 |
| F344 |
mean arterial blood pressure |
4-methyl-2-(piperidin-1-yl)-quinoline (1 mg/kg) (for 1 hours) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
arterial blood pressure trait |
male |
days
| 3 |
98.16 |
mmHg |
|
|
unspecified method |
0.0 |
|
|
|
105573 |
3018 |
| F344 |
ventricular late potential |
4-methyl-2-(piperidin-1-yl)-quinoline (1 mg/g) (for 0.5 hours) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
heart electrical impulse conduction trait |
male |
days
| 3 |
0.86 |
% |
0.21 |
0.36 |
electrocardiography |
0.0 |
|
|
CV% |
105580 |
3018 |
| F344 |
number of lower body licking events |
4-methyl-2-(piperidin-1-yl)-quinoline (1 mg/kg) (for 0.5 hours) then Allyl isothiocyanate (0.5 %) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
chemical nociception trait |
male |
days
| 4 |
2.0 |
null |
2.0 |
4.0 |
visual assessment of in vivo video recording |
1500.0 |
|
|
number of lower body licking events |
105556 |
3018 |
| F344 |
number of lower body licking events |
4-methyl-2-(piperidin-1-yl)-quinoline (0.75 mg/kg) (for 0.5 hours) then Allyl isothiocyanate (0.5 %) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
chemical nociception trait |
male |
days
| 3 |
19.25 |
null |
7.19 |
12.45 |
visual assessment of in vivo video recording |
1500.0 |
|
|
lower body licking event |
105561 |
3018 |
| F344 |
mean arterial blood pressure |
4-methyl-2-(piperidin-1-yl)-quinoline (1 mg/kg) (for 0.5 hours) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
arterial blood pressure trait |
male |
days
| 3 |
120.97 |
mmHg |
|
|
unspecified method |
0.0 |
|
|
|
105571 |
3018 |
| F344 |
measurement of the 50% threshold of mechanical stimulus needed to elicit evasive reaction |
4-methyl-2-(piperidin-1-yl)-quinoline (0.75 mg/kg) (for 0.5 hours) then Allyl isothiocyanate (0.5 null) (for 0.5 hours) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
tactile sensory behavior trait |
male |
days
| 4 |
14.77 |
g |
2.3 |
4.6 |
von Frey assay |
1500.0 |
|
von Frey assay (MMO:0000752) |
both paws |
105567 |
3018 |
| F344 |
number of abdominal retractions |
4-methyl-2-(piperidin-1-yl)-quinoline (0.5 mg/kg) (for 0.5 hours) then Allyl isothiocyanate (0.5 %) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
chemical nociception trait |
male |
days
| 4 |
31.67 |
null |
2.18 |
4.36 |
visual assessment of in vivo video recording |
1500.0 |
|
|
stretch/retract abdomon |
105558 |
3018 |
| F344 |
number of lower body licking events |
4-methyl-2-(piperidin-1-yl)-quinoline (0.5 mg/kg) (for 0.5 hours) then Allyl isothiocyanate (0.5 %) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
chemical nociception trait |
male |
days
| 4 |
21.67 |
null |
4.9 |
9.8 |
visual assessment of in vivo video recording |
1500.0 |
|
|
lower body licking event |
105555 |
3018 |
| F344 |
PR interval |
4-methyl-2-(piperidin-1-yl)-quinoline (1 mg/g) (for 0.5 hours) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
heart electrical impulse conduction trait |
male |
days
| 3 |
29.6 |
ms |
0.28 |
0.48 |
electrocardiography |
0.0 |
|
|
pq interval |
105584 |
3018 |
| F344 |
QRS duration |
4-methyl-2-(piperidin-1-yl)-quinoline (1 mg/g) (for 0.5 hours) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
heart electrical impulse conduction trait |
male |
days
| 3 |
15.41 |
ms |
0.56 |
0.97 |
electrocardiography |
0.0 |
|
|
pq interval |
105588 |
3018 |
| F344 |
measurement of the 50% threshold of mechanical stimulus needed to elicit evasive reaction |
4-methyl-2-(piperidin-1-yl)-quinoline (0.15 mg/kg) (for 0.5 hours) then Allyl isothiocyanate (0.5 %) (for 0.5 hours) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
tactile sensory behavior trait |
male |
days
| 4 |
11.35 |
g |
1.62 |
3.24 |
von Frey assay |
1500.0 |
|
von Frey assay (MMO:0000752) |
right paw |
109702 |
3018 |
| F344 |
number of abdominal retractions |
4-methyl-2-(piperidin-1-yl)-quinoline (0.75 mg/kg) (for 0.5 hours) then Allyl isothiocyanate (0.5 %) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
chemical nociception trait |
male |
days
| 4 |
32.5 |
null |
9.26 |
16.04 |
visual assessment of in vivo video recording |
1500.0 |
|
|
retract abdomen |
105563 |
3018 |
| F344 |
heart rate |
4-methyl-2-(piperidin-1-yl)-quinoline (1 mg/kg) (for 0.5 hours) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
heart pumping trait |
male |
days
| 3 |
424.89 |
beats/min |
2.65 |
4.59 |
electrocardiography |
0.0 |
|
|
|
105576 |
3018 |
| F344 |
QT interval |
4-methyl-2-(piperidin-1-yl)-quinoline (1 mg/g) (for 0.5 hours) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
heart electrical impulse conduction trait |
male |
days
| 3 |
72.02 |
ms |
1.68 |
2.91 |
electrocardiography |
0.0 |
|
|
|
105596 |
3018 |
| F344 |
measurement of the 50% threshold of mechanical stimulus needed to elicit evasive reaction |
4-methyl-2-(piperidin-1-yl)-quinoline (0.15 mg/kg) (for 0.5 hours) then Allyl isothiocyanate (0.5 %) (for 0.5 hours) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
tactile sensory behavior trait |
male |
days
| 4 |
10.85 |
g |
0.78 |
1.56 |
von Frey assay |
1500.0 |
|
von Frey assay (MMO:0000752) |
left paw |
109701 |
3018 |
| F344 |
number of lower body licking events |
4-methyl-2-(piperidin-1-yl)-quinoline (0.75 mg/kg) (for 0.5 hours) then Allyl isothiocyanate (0.5 %) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
chemical nociception trait |
male |
days
| 4 |
19.25 |
null |
4.9 |
7.19 |
visual assessment of in vivo video recording |
1500.0 |
|
|
licking abdomen events |
105565 |
3018 |
| F344 |
ST interval |
4-methyl-2-(piperidin-1-yl)-quinoline (1 mg/g) (for 0.5 hours) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
heart electrical impulse conduction trait |
male |
days
| 3 |
57.59 |
ms |
1.1 |
1.91 |
electrocardiography |
0.0 |
|
|
|
105592 |
3018 |