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LH/Mav
both kidneys wet weight to body weight ratio
streptozotocin (75 mg/kg) then hydralazine (75 mg/kg/d) (for 56 days) and controlled hydralazine content drinking water (15 mg/kg/d) (for 56 days) and reserpine (0.75 ml/kg/d) (for 56 days)
Emonnot L, et al., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3.
kidney mass
male
112 days
7
8.05
g/kg
0.24
0.63
post excision weight measurement
0.0
0
102697
2703
SHR/N-cp
both kidneys wet weight to body weight ratio
standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 140 and 154 days) then controlled hydralazine content drinking water (30 mg/l) (between 84 and 98 days) and hydralazine (50 mg/l) (between 84 and 98 days) and reserpine (4 mg/l) (between 84 and 98 days)
Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7.
kidney mass
male
140 days-168 days
8
1.83
g/kg
0.31
0.88
post excision weight measurement
0.0
0
101525
2601
LH/Mav
both kidneys wet weight to body weight ratio
controlled hydrochlorothiazide content drinking water (15 mg/kg/d) (for 63 days) and hydralazine (75 mg/kg/d) (for 63 days) and reserpine (0.75 mg/kg/d) (for 63 days) then controlled sodium content drinking water (2 %) (for 8 days)
Naelten G, et al., J Cardiovasc Pharmacol. 2011 Feb;57(2):240-5. doi: 10.1097/FJC.0b013e318204bb7b.
kidney mass
male
119 days
7
7.3
g/kg
0.09
0.24
post excision weight measurement
0.0
0
103423
2824