| F344/DuCrl |
methylene blue metabolism-surface area product without auto-oxidation |
methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77.0 days-91.0 days |
9 |
12.63 |
ml/min/kg |
1.99 |
5.98 |
isolated perfused lung vascular effluent collection |
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
58307 |
526 |
| F344/DuCrl |
methylene blue to FAPGG metabolism-surface area product ratio |
methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77.0 days-91.0 days |
9 |
0.22 |
null |
0.01 |
0.02 |
isolated perfused lung vascular effluent collection |
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
57736 |
526 |
| F344/DuCrl |
methylene blue to FAPGG metabolism-surface area product ratio |
controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77.0 days-91.0 days |
13 |
0.3 |
null |
0.03 |
0.11 |
isolated perfused lung vascular effluent collection |
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
58580 |
526 |
| F344/DuCrl |
methylene blue metabolism-surface area product after auto-oxidation |
controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77.0 days-91.0 days |
13 |
9.56 |
ml/min/kg |
0.78 |
2.82 |
isolated perfused lung vascular effluent collection |
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
59868 |
526 |
| F344/DuCrl |
methylene blue to FAPGG metabolism-surface area product ratio |
methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77.0 days-91.0 days |
9 |
0.15 |
null |
0.01 |
0.04 |
isolated perfused lung vascular effluent collection |
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
57741 |
526 |
| F344/DuCrl |
methylene blue to FAPGG metabolism-surface area product ratio |
controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77.0 days-91.0 days |
17 |
0.31 |
null |
0.02 |
0.07 |
isolated perfused lung vascular effluent collection |
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
58575 |
526 |
| F344/DuCrl |
methylene blue metabolism-surface area product without auto-oxidation |
controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77.0 days-91.0 days |
17 |
20.03 |
ml/min/kg |
1.59 |
6.54 |
isolated perfused lung vascular effluent collection |
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
58837 |
526 |
| F344/DuCrl |
methylene blue metabolism-surface area product without auto-oxidation |
controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77.0 days-91.0 days |
13 |
15.9 |
ml/min/kg |
1.49 |
5.37 |
isolated perfused lung vascular effluent collection |
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
58842 |
526 |
| F344/DuCrl |
methylene blue metabolism-surface area product after auto-oxidation |
controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77.0 days-91.0 days |
17 |
12.32 |
ml/min/kg |
0.86 |
3.54 |
isolated perfused lung vascular effluent collection |
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
59863 |
526 |
| F344/DuCrl |
methylene blue metabolism-surface area product after auto-oxidation |
methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
male |
77.0 days-91.0 days |
9 |
7.29 |
ml/min/kg |
0.83 |
2.49 |
isolated perfused lung vascular effluent collection |
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
57452 |
526 |
| F344/DuCrl |
methylene blue metabolism-surface area product after auto-oxidation |
methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77.0 days-91.0 days |
12 |
10.34 |
ml/min/kg |
1.4 |
4.85 |
isolated perfused lung vascular effluent collection |
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
57457 |
526 |
| F344/DuCrl |
methylene blue metabolism-surface area product without auto-oxidation |
methylene blue (10 umol/l) (between 0 and 0 hours) |
PhysGen Lung data |
pulmonary blood flow trait |
female |
77.0 days-91.0 days |
12 |
14.15 |
ml/min/kg |
1.66 |
5.76 |
isolated perfused lung vascular effluent collection |
|
|
Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan |
58312 |
526 |