| SHR/NCrl |
absolute change in mean arterial blood pressure |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
arterial blood pressure trait |
male |
87.0 days-120.0 days |
8 |
-25.11 |
mmHg |
3.07 |
8.68 |
vascular fluid filled catheter |
|
|
Moms and pups used in studies were fed Dyets |
50631 |
481 |
| SHR/NCrl |
absolute change in mean arterial blood pressure |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
arterial blood pressure trait |
female |
87.0 days-120.0 days |
6 |
-15.3 |
mmHg |
6.88 |
16.84 |
vascular fluid filled catheter |
|
|
Moms and pups used in studies were fed Teklad |
50809 |
481 |
| SHR/NCrl |
absolute change in heart rate |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
heart pumping trait |
male |
87.0 days-120.0 days |
6 |
12.15 |
beats/min |
5.65 |
13.83 |
vascular fluid filled catheter |
|
|
Moms and pups used in studies were fed Teklad |
50982 |
481 |
| SHR/NCrl |
absolute change in heart rate |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
heart pumping trait |
female |
87.0 days-120.0 days |
6 |
17.34 |
beats/min |
5.18 |
12.69 |
vascular fluid filled catheter |
|
|
Moms and pups used in studies were fed Teklad |
50985 |
481 |
| SHR/NCrl |
plasma renin activity level |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
renin activity |
male |
87.0 days-120.0 days |
5 |
6.62 |
ng/ml/h |
1.19 |
2.66 |
radioimmunoassay |
|
|
Moms and pups used in studies were fed Teklad |
51008 |
481 |
| SHR/NCrl |
plasma creatinine level |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
blood creatinine amount |
female |
87.0 days-120.0 days |
7 |
0.29 |
mg/dl |
0.01 |
0.02 |
radioimmunoassay |
|
|
Moms and pups used in studies were fed Dyets |
51175 |
481 |
| SHR/NCrl |
plasma renin activity level |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
renin activity |
female |
87.0 days-120.0 days |
7 |
10.95 |
ng/ml/h |
1.24 |
3.28 |
radioimmunoassay |
|
|
Moms and pups used in studies were fed Dyets |
50391 |
481 |
| SHR/NCrl |
mean arterial blood pressure |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
arterial blood pressure trait |
male |
87.0 days-120.0 days |
6 |
156.06 |
mmHg |
6.95 |
17.02 |
vascular fluid filled catheter |
|
|
Moms and pups used in studies were fed Teklad |
52002 |
481 |
| SHR/NCrl |
absolute change in mean arterial blood pressure |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
arterial blood pressure trait |
female |
87.0 days-120.0 days |
7 |
-23.04 |
mmHg |
2.62 |
6.92 |
vascular fluid filled catheter |
|
|
Moms and pups used in studies were fed Dyets |
50634 |
481 |
| SHR/NCrl |
plasma creatinine level |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
blood creatinine amount |
male |
87.0 days-120.0 days |
5 |
0.32 |
mg/dl |
0.01 |
0.01 |
radioimmunoassay |
|
|
Moms and pups used in studies were fed Dyets |
51181 |
481 |
| SHR/NCrl |
urine sodium excretion rate |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
urine sodium amount |
male |
87.0 days-120.0 days |
10 |
1.46 |
mEq/d |
0.11 |
0.36 |
flame atomic emission spectrometry |
|
|
Moms and pups used in studies were fed Dyets |
51270 |
481 |
| SHR/NCrl |
plasma creatinine level |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
blood creatinine amount |
female |
87.0 days-120.0 days |
5 |
0.29 |
mg/dl |
0.01 |
0.02 |
radioimmunoassay |
|
|
Moms and pups used in studies were fed Teklad |
51318 |
481 |
| SHR/NCrl |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87.0 days-120.0 days |
7 |
1.08 |
ml/min |
0.08 |
0.2 |
urine creatinine analysis |
|
|
Moms and pups used in studies were fed Dyets |
51544 |
481 |
| SHR/NCrl |
mean arterial blood pressure |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
arterial blood pressure trait |
female |
87.0 days-120.0 days |
7 |
117.77 |
mmHg |
2.86 |
7.56 |
vascular fluid filled catheter |
|
|
Moms and pups used in studies were fed Dyets |
51828 |
481 |
| SHR/NCrl |
absolute change in heart rate |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
heart pumping trait |
male |
87.0 days-120.0 days |
8 |
-6.87 |
beats/min |
2.38 |
6.72 |
vascular fluid filled catheter |
|
|
Moms and pups used in studies were fed Dyets |
51092 |
481 |
| SHR/NCrl |
mean arterial blood pressure |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
arterial blood pressure trait |
male |
87.0 days-120.0 days |
8 |
127.98 |
mmHg |
2.2 |
6.22 |
vascular fluid filled catheter |
|
|
Moms and pups used in studies were fed Dyets |
51825 |
481 |
| SHR/NCrl |
heart rate |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
heart pumping trait |
male |
87.0 days-120.0 days |
6 |
357.13 |
beats/min |
8.47 |
20.75 |
vascular fluid filled catheter |
|
|
Moms and pups used in studies were fed Teklad |
50883 |
481 |
| SHR/NCrl |
heart rate |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
heart pumping trait |
female |
87.0 days-120.0 days |
6 |
380.26 |
beats/min |
6.27 |
15.36 |
vascular fluid filled catheter |
|
|
Moms and pups used in studies were fed Teklad |
50886 |
481 |
| SHR/NCrl |
plasma renin activity level |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
renin activity |
female |
87.0 days-120.0 days |
6 |
3.33 |
ng/ml/h |
0.45 |
1.11 |
radioimmunoassay |
|
|
Moms and pups used in studies were fed Teklad |
51011 |
481 |
| SHR/NCrl |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87.0 days-120.0 days |
5 |
0.83 |
ml/min |
0.17 |
0.38 |
urine creatinine analysis |
|
|
Moms and pups used in studies were fed Teklad |
51057 |
481 |
| SHR/NCrl |
absolute change in heart rate |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
heart pumping trait |
female |
87.0 days-120.0 days |
7 |
-2.86 |
beats/min |
5.12 |
13.54 |
vascular fluid filled catheter |
|
|
Moms and pups used in studies were fed Dyets |
51095 |
481 |
| SHR/NCrl |
heart rate |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
heart pumping trait |
male |
87.0 days-120.0 days |
8 |
321.19 |
beats/min |
5.4 |
15.26 |
vascular fluid filled catheter |
|
|
Moms and pups used in studies were fed Dyets |
51249 |
481 |
| SHR/NCrl |
urine sodium excretion rate |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
urine sodium amount |
female |
87.0 days-120.0 days |
9 |
1.32 |
mEq/d |
0.09 |
0.28 |
flame atomic emission spectrometry |
|
|
Moms and pups used in studies were fed Dyets |
51273 |
481 |
| SHR/NCrl |
plasma creatinine level |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
blood creatinine amount |
male |
87.0 days-120.0 days |
5 |
0.28 |
mg/dl |
0.01 |
0.03 |
radioimmunoassay |
|
|
Moms and pups used in studies were fed Teklad |
51315 |
481 |
| SHR/NCrl |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
male |
87.0 days-120.0 days |
5 |
1.42 |
ml/min |
0.18 |
0.41 |
urine creatinine analysis |
|
|
Moms and pups used in studies were fed Dyets |
51550 |
481 |
| SHR/NCrl |
mean arterial blood pressure |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
arterial blood pressure trait |
female |
87.0 days-120.0 days |
6 |
137.69 |
mmHg |
5.58 |
13.68 |
vascular fluid filled catheter |
|
|
Moms and pups used in studies were fed Teklad |
52005 |
481 |
| SHR/NCrl |
absolute change in mean arterial blood pressure |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
arterial blood pressure trait |
male |
87.0 days-120.0 days |
6 |
-15.47 |
mmHg |
6.08 |
14.9 |
vascular fluid filled catheter |
|
|
Moms and pups used in studies were fed Teklad |
50806 |
481 |
| SHR/NCrl |
creatinine clearance |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
glomerular filtration trait |
female |
87.0 days-120.0 days |
4 |
0.59 |
ml/min |
0.17 |
0.33 |
urine creatinine analysis |
|
|
Moms and pups used in studies were fed Teklad |
51060 |
481 |
| SHR/NCrl |
heart rate |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
heart pumping trait |
female |
87.0 days-120.0 days |
7 |
355.95 |
beats/min |
5.94 |
15.72 |
vascular fluid filled catheter |
|
|
Moms and pups used in studies were fed Dyets |
51252 |
481 |
| SHR/NCrl |
urine sodium excretion rate |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
urine sodium amount |
male |
87.0 days-120.0 days |
8 |
1.08 |
mEq/d |
0.16 |
0.45 |
flame atomic emission spectrometry |
|
|
Moms and pups used in studies were fed Teklad |
51521 |
481 |
| SHR/NCrl |
urine sodium excretion rate |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
urine sodium amount |
female |
87.0 days-120.0 days |
9 |
1.03 |
mEq/d |
0.18 |
0.54 |
flame atomic emission spectrometry |
|
|
Moms and pups used in studies were fed Teklad |
51524 |
481 |
| SHR/NCrl |
plasma renin activity level |
controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) |
PhysGen Renal A data |
renin activity |
male |
87.0 days-120.0 days |
8 |
9.13 |
ng/ml/h |
0.66 |
1.87 |
radioimmunoassay |
|
|
Moms and pups used in studies were fed Dyets |
50396 |
481 |